Chao Zhang

The paper develops population-specific white matter charts for Chinese and Western populations, showing differences in maturation timing and improved prediction accuracy when using population-matched models.

Alpha Spatial predicts single-cell gene expression from histology using language-guided models, improving accuracy with matched biological context and outperforming existing methods in breast cancer analysis.

This study identifies a stable charge-anchored binding mode for FAP ligands, providing a framework for designing effective radiopharmaceuticals.

The paper tracks cortical computations during speech processing using a language model and MEG, finding comprehension sustains alignment in deep layers while acoustic processing remains unchanged without comprehension.

This study shows β-arrestin condensates regulate GPCR function through liquid-liquid phase separation, influencing internalization and signaling.

The paper uses whole-genome phylogenomic and synteny data to resolve the evolutionary origin of flatfish body asymmetry, finding strong support for a single origin.

The paper uses genomic data to determine whether flatfish asymmetry evolved once or multiple times, finding strong support for a single origin.

The paper investigates NRAC's role in reciprocal adipose-heart regulation of fatty acid metabolism across nutritional states using human and mouse data.

This paper reveals how mechanical force activates mGlu2 through a unique cis mechanism and induces distinct Gq coupling, providing structural insights and a chemical toolset for modulating mechanosensitive GPCRs.

Linkage is an R Shiny app and package that links ATAC-seq peaks to genes to identify cis-regulatory elements and transcription factor networks.

The paper identifies inherited defects in NK cells, antigen processing, and Wnt pathways that shape tumor immune microenvironment and clinical outcomes across 13 cancer types.

The paper uses whole genome trio sequencing to assess off-target effects of Cas9 editing in monkeys and finds no unexpected mutations.

This study shows that an acidic microenvironment, caused by lactate accumulation, promotes pluripotency in mouse and human ESCs through multiple mechanisms involving histone modification, mRNA stability, and microRNA regulation.

The paper examines the clk-1 gene's role in aging, showing individual variability in lifespan outcomes and categorizes lifespan curves into five patterns, with clk-1 mutants fitting the flattened pattern.

The paper uses Answer Set Programming to model nomenclatural changes in zoology, demonstrating how logic can infer and visualize compliance with nomenclatural rules in various scenarios.