Polyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Reversing Age-related Vision Decline
Fangyuan Gao, Emily Tom, Cezary Rydz, William Cho, Alexander V. Kolesnikov, Yutong Sha, Anastasios Papadam, Samantha Jafari, Andrew Joseph, Ava Ahanchi, Nika Balalaei Someh Saraei, David Lyon, Andrzej T. Foik, Nie Qing, Felix Grassmann, , Dorota Skowronska‐Krawczyk
This study shows that supplementing aged mice with 24:5n-3, a product of ELOVL2, improves visual function and reduces AMD-related protein accumulation, suggesting ELOVL2 as a therapeutic target for age-related vision loss.
bioRxiv · Jul 1, 2024 · PreprintMolecular Biology