William Cho

Reelin coordinates neuronal positioning and Müller glia scaffold maturation during retinal development

This study shows Reelin regulates retinal lamination by coordinating neuronal positioning and Müller glia scaffold maturation in mice.

The visual system of the longest-living vertebrate, the Greenland shark

This study shows the Greenland shark retains a functional visual system adapted to dim light, with intact rod-based vision genes and no retinal degeneration despite its age.

Impaired axonal transport at the optic nerve head contributes to neurodegeneration in a novel Cre-inducible mouse model of myocilin glaucoma

This study develops a novel Cre-inducible mouse model of myocilin glaucoma that replicates key human disease features, showing impaired axonal transport precedes retinal ganglion cell loss.

Polyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Reversing Age-related Vision Decline

This study shows that supplementing aged mice with 24:5n-3, a product of ELOVL2, improves visual function and reduces AMD-related protein accumulation, suggesting ELOVL2 as a therapeutic target for age-related vision loss.

Accelerated aging induced by stress in experimental murine ocular hypertension.

This study shows that repeated stress in young mice accelerates retinal aging at the transcriptional and epigenetic levels, highlighting the importance of early intervention for age-related eye diseases.