Author

Fernanda Martins Lopes

GlaxoSmithKline (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Alastair D. ReithiD· 1 shared Alice RockliffeiD· 1 shared Aurélie Schwartzentruber· 1 shared Benedetta Carbone· 1 shared Camilla BoschianiD· 1 shared Cuong Nguyen· 1 shared Elizabeth J. NewiD· 1 shared Fiona DucotterdiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alastair D. ReithORCID

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2 papers

Recent·Most cited

A CRISPR-CAS9 high throughput machine-learning platform for modulation of genes involved in Parkinson's disease-associated PINK1-mitophagy in iPSC-derived dopaminergic neurons

Marc P. M. Soutar, Benedetta Carbone, Petya Kindalova, Rahil Mehrizi, Fernanda Martins Lopes, Nathaniel Lam, Alice Rockliffe, Toni Braybrook, Matthew D. Taylor, Cuong Nguyen, Fiona Ducotterd, Alastair D. Reith, Lisa Mohamet, Hélène Plun‐Favreau

The paper develops a CRISPR-CAS9 platform with machine learning to study PINK1-mitophagy in Parkinson's disease using iPSC-derived neurons, identifying key genes and validating their roles.

bioRxiv · Jun 10, 2025 · PreprintNeuroscience

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons

Aurélie Schwartzentruber, Camilla Boschian, Fernanda Martins Lopes, Monika A. Myszczynska, Elizabeth J. New, Julien Beyrath, Jan A.M. Smeitink, Laura Ferraiuolo, Heather Mortiboys

The paper shows that PRKN mutations impair mitophagy in dopaminergic neurons during a metabolic switch to oxidative phosphorylation.

Scientific Reports · Sep 23, 2020Peer-reviewedNeuroscience