A CRISPR-CAS9 high throughput machine-learning platform for modulation of genes involved in Parkinson's disease-associated PINK1-mitophagy in iPSC-derived dopaminergic neurons
Marc P. M. Soutar, Benedetta Carbone, Petya Kindalova, Rahil Mehrizi, Fernanda Martins Lopes, Nathaniel Lam, Alice Rockliffe, Toni Braybrook, Matthew D. Taylor, Cuong Nguyen, Fiona Ducotterd, Alastair D. Reith, Lisa Mohamet, Hélène Plun‐Favreau
The paper develops a CRISPR-CAS9 platform with machine learning to study PINK1-mitophagy in Parkinson's disease using iPSC-derived neurons, identifying key genes and validating their roles.
bioRxiv · Jun 10, 2025 · PreprintNeuroscience