State-selective inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins
Yunxuan Zhang, Hannah L. Han, Lei Ortigosa-Pascual, Uri Z. Miles, Jiapeng Wei, Lexie E. Berkowicz, Finn Snow, Daizheng Tu, Georg Meisl, Shrutika Sansaria, Timothy J. Nott, Heike Laman, Randal Halfmann, Andrew C. McShan, Danny D. Sahtoe, Tuomas P. J. Knowles
This study designs de novo proteins that selectively inhibit alpha-synuclein aggregation by targeting specific intermediates, with one binder preferentially inhibiting oligomer formation and secondary nucleation.
bioRxiv · Sep 25, 2026 · PreprintBiophysics