Author
Stowers Institute for Medical Research
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Yunxuan Zhang, Hannah L. Han, Lei Ortigosa-Pascual…·Tuomas P. J. Knowles
This study designs de novo proteins that selectively inhibit alpha-synuclein aggregation by targeting specific intermediates, with one binder preferentially inhibiting oligomer formation and secondary nucleation.
Shriram Venkatesan, Alex T. Von Schulze, Jeffrey J. Lange…·Randal Halfmann
The paper shows that increasing translation initiation rates accelerates nucleation of aggregating proteins at polysomes, suggesting cotranslational nucleation influences proteome evolution.
Matthew W. Cotton, Shriram Venkatesan, Joseph S. Beckwith…·Georg Meisl
The paper identifies a cellular tipping point between aggregate accumulation and removal as a universal feature of neurodegeneration, validated through live-cell assays and super-resolution imaging.