Surveying the target tractability of cytokines with small molecules
Raavi, Sean P. Quinnell, Andrea Casiraghi, Becky S. Leifer, Benjamin Leu, Morgan Stilgenbauer, Fiona Wang, Haoyi Hou, Angela N. Koehler, Arturo J. Vegas
This study identifies small-molecule ligands and inhibitors for 32 cytokines, showing their tractability for small-molecule modulation and providing insights into chemical structures that enable cytokine inhibition.
bioRxiv · Apr 23, 2026 · PreprintImmunology