Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer
Yijuan Zhang, Ling Li, Swetha Maganti, Jennifer L. Hope, Cheska Marie Galapate, Florent Carrette, Karen Duong‐Polk, Anindya Bagchi, David A. Scott, Andrew M. Lowy, Linda M. Bradley, Cosimo Commisso
This study shows that macropinocytosis regulates CAF subtype identity under metabolic stress in PDAC, impacting tumor stroma and therapeutic response.
bioRxiv · Nov 29, 2024 · PreprintCancer Biology