BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity
Erwan Lambert, Carla Gelle, Valentin Leclerc…·Pierre Dourlen
This study shows that BIN1 isoform 1 expression in the presynaptic compartment causes synaptotoxicity, leading to synaptic loss and structural changes in Drosophila and rat models.