Franziska Witte

LINC01503-MP is a Mitochondrial Microprotein That Promotes Cell Proliferation and Oxidative Metabolism.

This study identifies LINC01503-MP, a mitochondrial microprotein derived from an lncRNA, which promotes cell proliferation and oxidative metabolism in colorectal cancer cells.

Trans control of cardiac mRNA translation in a protein length-dependent fashion

The paper identifies a trans locus in rats that causes a protein length-dependent shift in translational efficiency, affecting cardiac hypertrophy and sarcomere protein stoichiometry.

Identification of novel disease relevant genetic modifiers affecting the SHH pathway in the developing brain

The paper identifies Pttg1 and Ulk4 as genetic modifiers that enhance SHH pathway resilience and are involved in primary cilia formation in the neuroepithelium.

A functional screen of translated pancreatic lncRNAs identifies a microprotein-independent role for LINC00261 in endocrine cell differentiation

The paper identifies a microprotein-independent role for LINC00261 in endocrine cell differentiation during human pancreas development through genetic ablation of lncRNAs.

Translational control of cardiac fibrosis

The paper identifies translational regulators of fibrogenic genes in human cardiac fibroblasts and shows their role in cardiac fibrosis through ribosome profiling and RNA-binding protein analysis.