Annette Hammes

Mechanically-gated currents in mouse sensory neurons lacking PIEZO2

This study examines mechanosensitive currents in sensory neurons lacking PIEZO2, finding no significant reduction in current sensitivity but a moderate decrease in rapidly adapting currents.

Mechanosensitive PIEZO2 channels shape coronary artery development

This study shows PIEZO2 channels are critical for coronary artery development, as their absence causes vessel malformations and cardiac issues in mice.

Touch sensation requires the mechanically-gated ion channel Elkin1.

This study identifies Elkin1 as a novel mechanically-activated ion channel essential for touch and pain sensation, independent of Piezo2.

Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds

The paper investigates the role of Lrp2 in neural tube closure using mouse and Xenopus models, identifying its interaction with Shroom3 and Gipc1 and its role in apical constriction and planar cell polarity.

Identification of novel disease relevant genetic modifiers affecting the SHH pathway in the developing brain

The paper identifies Pttg1 and Ulk4 as genetic modifiers that enhance SHH pathway resilience and are involved in primary cilia formation in the neuroepithelium.