Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative disease
Li‐Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao, Hsin‐Fang Chang, Qilin Guo, Zhonghao Wu, Yixun Su, Na Zhao, Davide Gobbo, Amanda K. Wyatt, Vanessa Wahl, Frederic Fiore, Szu-Min Tu, Ulrich Boehm, , Xianshu Bai
The paper identifies a novel neuron-glia communication mechanism where neurons transfer lysosomes to OPCs, linking this process to neurodegenerative disease progression.
Nature Communications · Jan 30, 2025Peer-reviewedNeuroscience