Zhonghao Wu

Impaired astrocytic Cx43 syncytial network in lateral habenula affects synaptic connectivity and drives adolescent stress-induced depression

This study identifies impaired astrocytic Cx43 syncytial networks in the lateral habenula as a driver of adolescent stress-induced depression through disrupted synaptic connectivity and neuronal function.

Nuclear Cx43 restrains microglial neurotoxicity during brain development

This study identifies a nuclear function of Cx43 in microglia that restricts neurotoxicity during brain development, revealing a channel-independent mechanism involving transcriptional regulation.

A brain-tumour axis links chronic stress to gastric cancer progression through NPY signalling

The paper identifies a brain-tumour axis linking chronic stress to gastric cancer progression via NPY signalling, showing NPY1R as a therapeutic target.

Aberrant neuron-OPC synaptic transmission and deficient myelination define sex bias in major depressive disorder

This study identifies sex-specific mechanisms in major depressive disorder, highlighting impaired neuron-OPC communication and myelination in females.

Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative disease

The paper identifies a novel neuron-glia communication mechanism where neurons transfer lysosomes to OPCs, linking this process to neurodegenerative disease progression.

Oligodendroglial precursors orchestrate immune network instigating early demyelination in experimental autoimmune encephalomyelitis

This study identifies a network involving oligodendroglial precursors and immune cells that drives early demyelination in EAE, showing that targeting CCL4 disrupts this cycle.