Chitinase-3-like protein 1 decodes chitosan acetylation patterns into toll-like receptor 2 signaling through heparan sulfate
Alexandra Großdorf, Sina Nabil, Carlotta Imelmann, Margareta J. Hellmann, Jurij Froese, Ehab El‐Awaad, Tuan Anh Tran, Stefan Cord‐Landwehr, Nick Rähse, Önder Kurç, Fuzhu Yang, Hung-Yu Chen, Evelyne Gout, Gabriela Rosca, Marion Kusche‐Gullberg, , Christian Gorzelanny
This study shows CHI3L1 interacts with chitosan and heparan sulfate to activate TLR2 signaling, revealing HS as a co-receptor for CHI3L1 and its role in inflammation.
bioRxiv · Jun 16, 2026 · PreprintMolecular Biology