Author

Hung-Yu Chen

Institute of Biological Chemistry, Academia Sinica

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexander N.R. WeberiD· 1 shared Alexandra Großdorf· 1 shared Anayancy Osorio‐MadrazoiD· 1 shared Anthony A. KossiakoffiD· 1 shared Brian KlossiD· 1 shared Bruno Maria MoerschbacheriD· 1 shared Carlotta ImelmanniD· 1 shared Chelsea M. BrowniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Alexander N.R. WeberORCID

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2 papers

Recent·Most cited

Chitinase-3-like protein 1 decodes chitosan acetylation patterns into toll-like receptor 2 signaling through heparan sulfate

Alexandra Großdorf, Sina Nabil, Carlotta Imelmann, Margareta J. Hellmann, Jurij Froese, Ehab El‐Awaad, Tuan Anh Tran, Stefan Cord‐Landwehr, Nick Rähse, Önder Kurç, Fuzhu Yang, Hung-Yu Chen, Evelyne Gout, Gabriela Rosca, Marion Kusche‐Gullberg, , Christian Gorzelanny

This study shows CHI3L1 interacts with chitosan and heparan sulfate to activate TLR2 signaling, revealing HS as a co-receptor for CHI3L1 and its role in inflammation.

bioRxiv · Jun 16, 2026 · PreprintMolecular Biology

Structural insights into terminal arabinosylation biosynthesis of the mycobacterial cell wall arabinan

Yaqi Liu, Chelsea M. Brown, Satchal K. Erramilli, Yi-Chia Su, Shih-Yun Guu, Po‐Sen Tseng, Yu-Jen Wang, Nam Ha Duong, Piotr Tokarz, Brian Kloss, Cheng-Ruei Han, Hung-Yu Chen, José Rodrigues, Kay‐Hooi Khoo, Margarida Archer, , Filippo Mancia

This study presents cryo-EM structures of AftB from Mycobacterium chubuense, revealing its architecture and mechanism for terminal arabinosylation in mycobacterial cell wall biosynthesis.

Nature Communications · Apr 29, 2025Peer-reviewedBiochemistry