Cancer BiologybioRxiv
Drug-induced adaptation along a resistance continuum in cancer cells
G. S. Franca, M. Baron, M. Pour…·I. Yanai
This study shows that gradual dose exposure and prolonged treatment drive ovarian cancer cell resistance to targeted therapy through a continuous adaptation process involving transcriptional, epigenetic, and genetic changes.
DOI 10.1038/s41586-024-07690-9