A. Rao

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.

A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.

Shared features of blastula and neural crest stem cells evolved at the base of vertebrates

This study compares gene regulatory networks of neural crest and pluripotency stem cells in jawed and jawless vertebrates, revealing shared evolutionary origins and functional roles of pou5 in neural crest development.

Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response

This study shows BET inhibition reduces E6 and E7 expression in HPV-16 HNSCC, with variable effects on p53 and Rb, and induces G1 arrest and apoptosis.

Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models

The paper presents a single-cell RNA-sequencing dataset of human and mouse adipogenesis models, revealing three cell clusters during differentiation.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis

This study uses single-cell and spatial multi-omics to show VDZ affects mononuclear phagocyte subsets and highlights gene expression patterns in UC.

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

The paper analyzes donor pancreata to define the transcriptomic signature and microenvironment of early pre-neoplastic lesions, finding PanIN lesions are common in healthy individuals and show transcriptional similarity to cancer cells.

Sirtuin 2 inhibition modulates chromatin landscapes genome- wide to induce senescence in ATRX-deficient malignant glioma

This study shows that SIRT2 inhibition induces senescence in ATRX-deficient glioma models by altering chromatin landscapes and transcriptional profiles.

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

The paper identifies shared molecular features between H3K27M diffuse midline gliomas and PFA ependymomas, linking them to hindbrain developmental pathways.

Drug-induced adaptation along a resistance continuum in cancer cells

This study shows that gradual dose exposure and prolonged treatment drive ovarian cancer cell resistance to targeted therapy through a continuous adaptation process involving transcriptional, epigenetic, and genetic changes.

Thymic Rejuvenation by Adult Grafts in the Lymph Node

This study transplants adult mouse thymuses into lymph nodes of athymic mice, finding that younger thymus grafts rejuvenate thymic function and T cell activation, while older grafts show limited regeneration.

Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests

Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

This study shows hypoxia drives an inflammatory phenotype in pancreatic cancer-associated fibroblasts, promoting tumor IL1 expression and iCAF formation in hypoxic regions.

PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells.

This study shows PSGL-1 modulates TCF-1/TOX axis to repress metabolism and promote T cell exhaustion in CD8+ T cells, making it a therapeutic target for PD-1/PD-L1 resistant tumors.

Recurrence of cancer cell states across diverse tumors and their interactions with the microenvironment

The paper identifies recurrent cancer cell states across 15 tumor types and examines their interactions with the tumor microenvironment using single-cell RNA-Seq and spatial transcriptomics.

OGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis

This study identifies OGT's role in maintaining cell viability by regulating the proteasome/mTOR/mitochondrial axis through amino acid homeostasis and mitochondrial fitness.

Subclonal evolution and expansion of THY1-positive cells is associated with recurrence in glioblastoma

This paper identifies THY1-positive, mesenchymal/stem-like cells as drivers of glioblastoma recurrence and shows that targeting TGFβ signaling can restore sensitivity to therapy.

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

The transcriptional cofactor IRF2BP2 plays a key role in T cell homeostasis and Treg cell expansion

This study shows that IRF2BP2 overexpression in T cells reduces proliferation, increases Tregs, and dampens autoimmune inflammation.

Novel antibodies for the simple and efficient enrichment of native O-GlcNAc modified peptides

The paper introduces new anti-O-GlcNAc antibodies for efficient enrichment of native O-GlcNAc modified peptides, identifying over 1,300 unique peptides with reduced sample and time requirements.

Intriguing effects of selection intensity on the evolution of prosocial behaviors

This paper investigates how intermediate selection intensities affect the evolution of prosocial behaviors, finding that a balance between drift and selection can promote altruistic traits in previously unconducive models.

Active Enterohepatic Cycling is Not Required for the Choleretic Actions of 24-norUrsodeoxycholic Acid in Mice

This study shows that norUDCA induces bile flow and bicarbonate secretion in mice without requiring ASBT or OST, suggesting these transporters are not directly involved in its choleretic actions.

A Structured Professional Development Curriculum for Postdoctoral Fellows Leads to Recognized Knowledge Growth

A structured professional development curriculum for postdocs leads to measurable knowledge growth compared to non-participants.

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

This study shows that melanoma metastasis is promoted by heterotypic clusters formed between proliferative and invasive cell states, mediated by TFAP2.

Role of Anti-SARS-CoV-2 antibodies in different cohorts: Can they provide clues for appropriate patient triaging?

This study examines the correlation between anti-SARS-CoV-2 antibodies and molecular testing in different patient cohorts to assess their utility in patient triaging.

Mobilization of tissue-resident memory CD4+ T lymphocytes and their contribution to a systemic secondary immune reaction

The paper shows that tissue-resident memory CD4+ T cells mobilize into the blood after vaccination and contribute to systemic secondary immune responses.

Determination of secretory granule maturation times in pancreatic islet beta-cells by serial block face scanning electron microscopy

The paper uses SBEM to determine secretory granule maturation times in mouse pancreatic beta-cells, finding immature granules remain in their state for about 2 hours before transforming.

Multispectral Imaging Differentiates Unique Macrophage Profiles in Patients with Distinct Chronic Liver Diseases

This study uses multispectral imaging to analyze macrophage profiles in liver biopsies from patients with chronic liver diseases, revealing distinct macrophage phenotypes associated with different fibrosis stages and disease types.

Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo.

The paper investigates how adaptive substitutions in Na+,K+-ATPase affect cardiac glycoside insensitivity in insects, revealing epistatic interactions that constrain evolution.