Telomerase reverse transcriptase induces targetable alterations in glutathione and nucleotide biosynthesis in glioblastomas
S. Udutha, C. Taglang, G. Batsios, A. M. Gillespie, M. Tran, S. M. Ronen, J. ten Hoeve, T. G. Graeber, P. Viswanath
This study identifies metabolic vulnerabilities in glioblastomas driven by TERT and shows that combining GCLC and glutamine-utilizing enzyme inhibitors synergistically targets these vulnerabilities.
bioRxiv · Nov 14, 2023 · PreprintCancer Biology