M. Tran

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

Gentle rhodamines for live-cell fluorescence microscopy

This paper introduces Gentle Rhodamines with reduced phototoxicity for live-cell imaging, enabling time-lapse and voltage imaging with less cellular damage.

In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.

Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues

This study benchmarks three imaging spatial transcriptomics platforms on FFPE tissues, finding 10x Xenium has higher transcript counts without sacrificing specificity, while all platforms align with RNA-seq data but vary in performance metrics.

Telomerase reverse transcriptase induces targetable alterations in glutathione and nucleotide biosynthesis in glioblastomas

This study identifies metabolic vulnerabilities in glioblastomas driven by TERT and shows that combining GCLC and glutamine-utilizing enzyme inhibitors synergistically targets these vulnerabilities.

Fluorescent pH-sensing bandage for point-of-care wound diagnostics

This paper develops a fluorescent pH-sensing bandage for diagnosing diabetic foot ulcers by detecting pH changes in wounds.

Histone deacetylase 3 plays a critical role in hypertension-induced kidney inflammation and fibrosis

This study shows that myeloid HDAC3 deficiency protects against angiotensin II-induced kidney inflammation and fibrosis in mice.

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

This study determines the cryo-EM structures of human 12-LOX, revealing its oligomeric states, catalytic mechanism, and inhibitor binding, which informs drug development.

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

This paper identifies a mechanism by which oxysterols like 25HC deplete accessible cholesterol from plasma membranes via ACAT activation and SREBP suppression to restrict microbial infection.

HSV Tegument Protein pUL51 Interacts with Host Dynactin for Viral Spread

This study identifies an interaction between HSV-1 protein pUL51 and host dynactin subunit p150Glued, essential for viral spread, and shows that disrupting this interaction inhibits HSV growth and spread.

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

Electrical signature of heterogeneous human mesenchymal stem cells

This study uses dielectrophoresis to quantify heterogeneity in human mesenchymal stem cells and links electrical properties to differentiation potential.

Pan-cancer imaging of TERT expression using deuterium magnetic resonance spectroscopy-based assessment of pyruvate metabolism

This study links TERT expression to NADH levels via FOXO1 and demonstrates 2H-MRS as a non-invasive method to image TERT in multiple cancers.

Systematic Tuning of Rhodamine Spirocyclization for Super-Resolution Microscopy

This paper describes a method to systematically tune the spirocyclization equilibrium of rhodamines to create probes for different super-resolution microscopy techniques.

Efficient reprogramming of the heavy-chain CDR3 regions of a human antibody repertoire

The paper reprograms human B cells to express HCDR3 regions of HIV-1 bNAbs, enabling diverse and physiologic repertoires that efficiently bind HIV-1 antigens.

Spatial analysis of ligand-receptor interaction in skin cancer at genome-wide and single-cell resolution

The paper develops a toolbox to study cancer-immune cell communication using multimodal data and a computational method called STRISH, validated on basal and squamous cell carcinomas.

Menthol in Electronic Cigarettes: A Contributor to Respiratory Disease?

This study investigates how menthol in e-cigarettes affects human bronchial epithelium using three in vitro models, finding adverse effects including oxidative stress and inflammation.

A general strategy to develop cell permeable and fluorogenic probes for multi-colour nanoscopy

The paper develops a strategy to create fluorogenic probes for live-cell nanoscopy with high cell permeability and low background signal.