Stat2 loss disrupts damage signalling and is protective in acute pancreatitis
H. Heath, G. Britton, H. Kudo, G. Renney, M. Ward, R. Hutchins, G. Foster, R. Goldin, W. Alazawi
This study shows that Stat2 deficiency protects against acute pancreatitis by disrupting damage signaling pathways independent of type I interferon, with reduced cytokine levels and NF-κB activation.
bioRxiv · Sep 18, 2019Immunology