Establishment of multiple novel patient-derived models of desmoplastic small round cell tumor enabling functional characterization of ERBB pathway signaling and pre-clinical evaluation of a novel targeted therapy approach
R. S. Smith, I. Odintsov, Z. Liu, T. Hayashi, A. J. W. Lui, M. Vojnic, Y. Suehara, M. S. Mattar, J. Hmeljak, H. A. Ramirez, M. Shaw, G. Bui, A. B. Hartono, E. Gladstone, H. Magnan, , R. Somwar
This study develops new DSRCT models and shows that targeting the ERBB pathway with EGFR inhibitors reduces tumor growth in preclinical models.
bioRxiv · Sep 22, 2020 · PreprintCancer Biology