M. Shaw

The influence of internal pressure and neuromuscular agents on C. elegans biomechanics: an empirical and multi-compartmental in silico modelling study

This study combines indentation experiments and in silico modelling to investigate the biomechanics of C. elegans, revealing how internal pressure and neuromuscular agents affect tissue stiffness.

Nanoprojectile Secondary Ion Mass Spectrometry Enables Multiplexed Analysis of Individual Hepatic Extracellular Vesicles

This study uses NP-SIMS to analyze single hepatic extracellular vesicles, distinguishing between normal and cancerous EVs based on surface marker expression.

Standing wave mesoscopy

This paper introduces a mesoscale version of standing wave microscopy, enabling high-resolution imaging of large cell populations in fixed and living specimens under flow conditions.

Metagenomic analysis of concrete bridge reveals a microbial community dominated by halophilic Bacteria and Archaea

The paper improves DNA extraction from concrete to enable shotgun metagenomic sequencing, revealing a halophilic microbial community dominated by Bacteria and Archaea with osmotic stress-related functions.

A deep learning pipeline for segmentation of Proteus mirabilis colony patterns

This paper develops a deep learning pipeline to segment macroscopic colony patterns of Proteus mirabilis, achieving high accuracy in identifying colony boundaries and internal ring structures.

Microenvironmental correlates of immune checkpoint inhibitor response in human melanoma brain metastases revealed by T cell receptor and single-cell RNA sequencing

mmSIM: An open toolbox for accessible structured illumination microscopy

The paper introduces mmSIM, an open-source software suite for structured illumination microscopy, enabling easier development and operation of custom SIM systems.

Establishment of multiple novel patient-derived models of desmoplastic small round cell tumor enabling functional characterization of ERBB pathway signaling and pre-clinical evaluation of a novel targeted therapy approach

This study develops new DSRCT models and shows that targeting the ERBB pathway with EGFR inhibitors reduces tumor growth in preclinical models.