Pharmacological control of CAR T cells through CRISPR-driven rapamycin resistance
S. Levesque, G. Carleton, V. Duque, C. Goupil, J.-P. Fiset, S. Villeneuve, E. Normandeau, G. Morin, N. Dumont, B. H. Nelson, J. Laganiere, B. Boyle, J. J. Lum, Y. Doyon
This study develops a CRISPR-based method to create rapamycin-resistant CAR-T cells, enabling pharmacological control of their activity in cancer therapy.
bioRxiv · Sep 14, 2023 · PreprintCancer Biology