Glucose-6-phosphate dehydrogenase deficiency accelerates pancreatic acinar-to-ductal metaplasia
M. D. Radyk, B. S. Nelson, C. J. Halbrook, A. Wood, B. Lavoie, L. Salvatore, G. Corfas, J. Colacino, Y. M. Shah, H. C. Crawford, C. A. Lyssiotis
This study shows that G6PD deficiency accelerates pancreatic acinar-to-ductal metaplasia by enhancing NADPH production for ROS management, highlighting a metabolic role in early tumorigenesis.
bioRxiv · Nov 6, 2023 · PreprintCancer Biology