Y. M. Shah

This study shows that sulfide oxidation via SQOR promotes hypoxic angiogenesis and neovascularization by reprogramming metabolic pathways in endothelial cells.

This study shows that G6PD deficiency accelerates pancreatic acinar-to-ductal metaplasia by enhancing NADPH production for ROS management, highlighting a metabolic role in early tumorigenesis.

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

This study shows PINK1 supports colorectal cancer growth by regulating the labile iron pool through mitophagy and ferritinophagy.

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

This study identifies reuterin as a microbial metabolite that suppresses colorectal cancer growth by altering redox balance and inducing cell death.

This study shows HIF-2 regulates intestinal ferritinophagy via NCOA4, which is essential for systemic iron homeostasis.

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

This study shows that inhibiting GOT1 in pancreatic cancer primes cells for ferroptosis by promoting autophagy-mediated release of labile iron.

This study shows that HIF-2α overexpression makes colon cancer cells more sensitive to oxidative cell death, suggesting a potential therapeutic strategy.

This study shows cadmium exposure inhibits branching morphogenesis and HIF-1α activity in human breast organoids, suggesting it disrupts mammary gland development rather than promoting cancer.

The paper isolates and characterizes LGR5-positive cells from human colon adenomas using organoids and RNA-sequencing, identifying correlations with CRC-specific genes.