Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
G. Zurawska, Z. Sas, A. Jonczy, R. Mahadeva, P. Slusarczyk, M. Chwalek, D. Seehofer, G. Damm, M. Kulecka, I. Rumienczyk, M. Moulin, K. Jastrzebski, M. Mikula, A. Etzerodt, R. Serwa, , K. Mleczko-Sanecka
This study identifies liver sinusoidal endothelial cells as the primary cells responsible for hemoglobin clearance, revealing their role in heme detoxification and iron homeostasis through macropinocytosis and the BMP6-hepcidin axis.
bioRxiv · Nov 14, 2023Cell Biology