Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions
L. M. Mus, S. Van Haver, M. Popovic, W. Trypsteen, S. Lefever, N. Zeltner, Y. Ogando, E. Z. Jacobs, G. Denecker, E. Sanders, C. Van Neste, S. Vanhauwaert, B. Decaesteker, D. Deforce, F. Van Nieuwerburgh, , F. Speleman
This study shows that chromosomal imbalances in hESCs provide a proliferative advantage under replicative stress, similar to cancer cells.
bioRxiv · Nov 6, 2020Cancer Biology