MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells
S. Zanotti, S. Vanhauwaert, C. Van Neste…·F. Speleman
This study shows that MYCN activation in RPE cells causes nucleolar stress and a senescence-like transcriptional program without full senescence hallmarks, leading to growth attenuation.