J. Roels

Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

Trans-synaptic dwelling of SARS-CoV-2 particles perturbs neural synapse organization and function

The paper shows that SARS-CoV-2 exposure perturbs neural synapse organization and electrical activity by lodging at trans-synaptic interfaces.

Single-cell profiling identifies a spectrum of human unconventional intraepithelial T lineage cells

The paper identifies a spectrum of human unconventional intraepithelial T lineage cells using single-cell RNA sequencing and defines their phenotypic and transcriptomic features.

An interactive mass spectrometry atlas of histone posttranslational modifications in T-cell acute leukemia

The paper presents a comprehensive mass spectrometry-based atlas of histone posttranslational modifications in T-cell acute lymphoblastic leukemia cell lines, providing a reusable dataset for epidrug development.

SOX11 is a lineage-dependency factor and master epigenetic regulator in neuroblastoma

This study identifies SOX11 as a critical transcription factor and epigenetic regulator in adrenergic neuroblastoma, showing its role in chromatin accessibility and cell identity.

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors.

The paper uses single-cell RNA sequencing to analyze immature human thymocytes and identifies thymus seeding precursors and T-lineage developmental pathways.