Neurovirulence of the Australian outbreak Japanese Encephalitis virus genotype 4 is lower compared to genotypes 2 and 3 in mice and human cortical brain organoids
W. Nguyen, N. Gyawali, R. Stewart, B. Tang, A. L. Cox, K. Yan, T. Larcher, C. R. Bishop, N. Wood, G. Devine, A. Suhrbier, D. J. Rawle
This study compares the neurovirulence of JEV genotype 4 (JEVNSW/22) with genotypes 2 and 3 in mice and human brain organoids, finding JEVNSW/22 less neurovirulent and more sensitive to type I interferon.
bioRxiv · Apr 26, 2023 · PreprintMicrobiology