Author

W. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Organism:plant (other)· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. E. Barry· 2 shared A. Suhrbier· 2 shared B. E. Sleebs· 2 shared B. S. Crabb· 2 shared B. Tang· 2 shared C. R. Bishop· 2 shared D. B. Ling· 2 shared D. J. Rawle· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. E. Barry

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

M. G. Dans, C. Boulet, G. M. Watson, W. Nguyen, J. M. Dziekan, C. Evelyn, K. Reaksudsan, S. Mehra, Z. Razook, N. D. Geoghegan, M. J. Mlodzianoski, C. D. Goodman, D. B. Ling, T. K. Jonsdottir, J. Tong, , P. R. Gilson

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

bioRxiv · Nov 2, 2023 · PreprintCell Biology

Neurovirulence of the Australian outbreak Japanese Encephalitis virus genotype 4 is lower compared to genotypes 2 and 3 in mice and human cortical brain organoids

W. Nguyen, N. Gyawali, R. Stewart, B. Tang, A. L. Cox, K. Yan, T. Larcher, C. R. Bishop, N. Wood, G. Devine, A. Suhrbier, D. J. Rawle

This study compares the neurovirulence of JEV genotype 4 (JEVNSW/22) with genotypes 2 and 3 in mice and human brain organoids, finding JEVNSW/22 less neurovirulent and more sensitive to type I interferon.

bioRxiv · Apr 26, 2023 · PreprintMicrobiology

A pyridyl-furan series developed from Open Global Health Library blocks red blood cell invasion and protein trafficking in Plasmodium falciparum through potential inhibition of the parasites PI4KIIIb enzyme.

D. B. Ling, W. Nguyen, O. Looker, Z. Razook, K. McCann, A. E. Barry, C. Scheurer, S. Wittlin, H. E. Bullen, B. S. Crabb, B. E. Sleebs, P. R. Gilson

The paper identifies a pyridyl-furan compound series that inhibits Plasmodium falciparum growth and red blood cell invasion by targeting the PI4KIIIb enzyme.

bioRxiv · Apr 25, 2023Microbiology

Increased neurovirulence of omicron BA.5 and XBB variants over BA.1 in K18-hACE2 mice and human brain organoids

R. Stewart, K. Yan, S. A. Ellis, C. R. Bishop, T. Dumenil, B. Tang, W. Nguyen, T. Larcher, R. Parry, J. D. J. Sng, A. A. Khromykh, R. K. P. Sullivan, M. Lor, F. A. Meunier, D. J. Rawle, A. Suhrbier

This study shows that omicron BA.5 and XBB variants are more neurovirulent than BA.1 in mice and human brain organoids, leading to increased brain infection and mortality.

bioRxiv · Dec 22, 2022 · PreprintMicrobiology