A genome-wide CRISPR screen identifies ZCCHC14 as a host factor required for hepatitis B surface antigen production
A. Hyrina, C. Jones, D. Chen, S. Clarkson, N. Cochran, P. Feucht, G. Hoffman, A. Lindeman, C. Russ, F. Sigoillot, K. Uehara, L. Xie, D. Ganem, M. Holdorf
The paper uses a genome-wide CRISPR screen to identify ZCCHC14 as a host factor required for hepatitis B surface antigen production and shows it stabilizes HBsAg through RNA tailing with TENT4A/B.
bioRxiv · Jul 30, 2019Microbiology