C. Jones

The impact of transplant location on the gut microbiome and resistome in patients undergoing hematopoietic stem cell transplantation at home versus in the hospital

This study compares the gut microbiome and resistome of patients undergoing home versus hospital hematopoietic stem cell transplantation, finding no significant differences but noting confounding factors in secondary analyses.

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

The renal capsule, a vibrant and adaptive cell environment of the kidney in homeostasis and aging

This study characterizes the renal capsule's cellular composition and dynamics in health, aging, and disease, revealing its adaptive responses and age-related changes.

MERISTEM-DEFECTIVE/DEFECTIVELY ORGANIZED TRIBUTARIES2 regulates the balance between stemness and differentiation in the root meristem through RNA splicing control.

This study identifies MDF as a splicing factor regulating root meristem function in Arabidopsis by controlling splicing of RSZ33, ACC1, and SR34, balancing stemness and stress response.

Targeted metagenomics using probe capture detect a larger diversity of nitrogen and methane cycling genes in complex microbial communities than traditional metagenomics

This paper introduces a targeted metagenomics approach using probe capture to enhance the detection of nitrogen and methane cycling genes in complex microbial communities, showing higher diversity and sequence coverage compared to traditional methods.

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

Stu2 has an essential kinetochore role independent of regulating microtubule dynamics

This study identifies Stu2's essential kinetochore function independent of its microtubule dynamics regulation through separation-of-function mutants and artificial tethering.

Design of an Integrated Microvascularised Human Skin-on-a-Chip Tissue Equivalent Model

This paper designs a microvascularised human skin-on-a-chip model and shows that vascularization improves epidermal stratification and differentiation in vitro.

Quantification of spatial subclonal interactions enhancing the invasive phenotype of paediatric glioma

This study quantifies spatial subclonal interactions in paediatric gliomas that enhance invasive phenotype, distinguishing true interactions from spatial confounding factors.

Loss of the H4 lysine methyltransferase KMT5B drives tumorigenic phenotypes by depleting H3K27me3 at loci otherwise retained in H3K27M mutant DIPG cells

The paper shows that loss of KMT5B in DIPG cells depletes retained H3K27me3 loci, leading to transcriptional changes that promote tumorigenesis.

The influence of sex, hormone status, and growth rate on dietary isotope fractionation: a case study with laboratory rats

This study investigates how sex, hormone status, and growth rate influence isotopic fractionation in laboratory rats, showing that gonadal hormones affect δ15N and δ13C values in tissues.

A Kernel-Based Change Detection Method to Map Shifts in Phytoplankton Communities Measured by Flow Cytometry

This paper introduces CytoSegmenter, a kernel-based method for segmenting flow cytometry point cloud data to detect shifts in phytoplankton communities, showing these shifts correlate with ocean temperature and salinity changes.

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

In vitro assessment of the virucidal activity of four mouthwashes containing Cetylpyridinium Chloride, ethanol, zinc and a mix of enzyme and proteins against a human coronavirus

This study assesses the virucidal activity of four mouthwashes against a human coronavirus surrogate, finding that 0.07% Cetylpyridinium Chloride mouthwash reduces viral counts by ≥3.0 log.

A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

This study identifies a distinct subset of pediatric gliomas with EGFR alterations, H3K27me3 loss, and broad tumor localization, suggesting EGFR inhibition as a potential therapy.

Kill and cure: genomic phylogeny and bioactivity of a diverse collection of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles

This study examines the genomic phylogeny and bioactivity of 206 Burkholderia gladioli strains, identifying toxin-producing clades and potential therapeutic strategies for CF-related infections.

Infestation dynamics between parasitic Antarctic fish leeches (Piscicolidae) and their crocodile icefish hosts (Channichthyidae)

This study examines leech infestation patterns in Antarctic fish hosts, revealing attachment site fidelity and suggesting trophic transmission as key factors in parasitization.

Stock mislabelling and its impact on phylogenomic analysis in the Drosophila nasuta subgroup/species complex

The paper identifies mislabeled Drosophila stocks and shows how alignment-free phylogenomic analysis clarifies their true origins.

A genome-wide CRISPR screen identifies ZCCHC14 as a host factor required for hepatitis B surface antigen production

The paper uses a genome-wide CRISPR screen to identify ZCCHC14 as a host factor required for hepatitis B surface antigen production and shows it stabilizes HBsAg through RNA tailing with TENT4A/B.

The effects of soil phosphorous content on microbiota are driven by the plant phosphate starvation response

This study investigates how soil phosphorous content affects plant microbiota, finding that plant phosphate starvation response has a greater impact than soil P levels themselves.

Validation of the protein kinase PfCLK3 as a multi-stage cross species malarial drug target

This study identifies PfCLK3 as a druggable target for malaria by showing its essential role in multiple parasite life stages across species.

Population and individual effects of non-coding variants inform genetic risk factors

The paper identifies non-coding variants affecting gene expression in Sardinian individuals and links them to population history and genetic risk.