Author

G. Kinsler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Assay:bulk RNA-seq· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

D. Newell· 2 shared D. Petrov· 2 shared K. Geiler-Samerotte· 2 shared K. Schmidlin· 2 shared S. Apodaca· 2 shared A. Sastokas· 1 shared M. Tikhonov· 1 shared R. Eder· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 22 mutual co-author links

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2 shared papersEvolutionary Biology

D. Newell

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3 papers

Recent·Most cited

Improving the accuracy of bulk fitness assays by correcting barcode processing biases

R. S. McGee, G. Kinsler, D. Petrov, M. Tikhonov

The paper develops a computational method to correct barcode processing biases in bulk fitness assays, improving fitness estimates in yeast variant libraries.

bioRxiv · Oct 31, 2023Evolutionary Biology

Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

K. Schmidlin, S. Apodaca, D. Newell, A. Sastokas, G. Kinsler, K. Geiler-Samerotte

The paper identifies distinct fitness tradeoff groups among fluconazole-resistant yeast mutants, suggesting different resistance mechanisms and implications for multidrug therapy design.

bioRxiv · Oct 17, 2023Evolutionary Biology

Extreme sensitivity of fitness to environmental conditions; lessons from #1BigBatch

G. Kinsler, K. Schmidlin, D. Newell, R. Eder, S. Apodaca, D. Petrov, K. Geiler-Samerotte

This study identifies environmental variability as a major source of noise in fitness measurements and proposes best practices for improving precision.

bioRxiv · Aug 25, 2022Evolutionary Biology