Hypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung Cancer
J. Levallet, T. Biojout, C. Bazille, M. Douyere, F. Dubois, D. Leite Ferreira, J. Taylor, S. Teulier, J. Toutain, M. Bernaudin, S. Valable, E. Bergot, G. Levallet
This study identifies hypoxia-induced NDR2 activation as a driver of brain metastases in NSCLC, showing NDR2 overexpression correlates with metastatic potential and can be measured via immunohistochemistry.
bioRxiv · Mar 20, 2023Cancer Biology