Myeloperoxidase promotes a tumorigenic microenvironment in non-small cell lungcancer
P. Valadez-Cosmes, M. Kathrin, O. Kindler, N. Cosic-Mujkanovic, A. Lueger, S. Raftopoulou, M. Kienzl, Z. N. Mihalic, A. Santiso, A. Sarsembayeva, L. Brcic, J. Lindenmann, W. Sattler, A. Heinemann, R. Schicho, , J. Kargl
The paper shows high MPO expression in NSCLC predicts poor outcomes and MPO deficiency in mice enhances anti-tumorigenic immune infiltration, suggesting MPO promotes a pro-tumorigenic microenvironment.
bioRxiv · Jan 28, 2023Cancer Biology