Liver humanized NSG-PiZ mice support the study of chronic hepatitis B virus infection and antiviral therapies
R. Colon-Thillet, D. Stone, M. A. Loprieno, L. Klouser, P. Roychoudhury, T. K. Santo, H. Xie, L. Stensland, S. L. Upham, G. Pepper, M. Huang, M. Aubert, K. R. Jerome
This study shows liver-humanized NSG-PiZ mice can support chronic HBV infection and antiviral therapy research, with prolonged viremia and responsiveness to entecavir.
bioRxiv · May 17, 2022 · PreprintMicrobiology