Author

G. Pickersgill

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

G. P. Cook· 1 shared H. C. Hope· 1 shared N. Vannini· 1 shared P. Ginefra· 1 shared R. J. Salmond· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

G. P. Cook

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1 paper

Recent·Most cited

TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells

H. C. Hope, G. Pickersgill, P. Ginefra, N. Vannini, G. P. Cook, R. J. Salmond

This study shows TGFβ suppresses Myc-driven metabolic changes in CD8+ T cells during activation by blocking amino acid uptake and glycolysis, while sparing mitochondrial respiration and mTOR activation.

bioRxiv · Mar 30, 2022Immunology