Author

H. C. Hope

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

R. J. Salmond· 2 shared G. P. Cook· 1 shared G. Pickersgill· 1 shared L. Steele· 1 shared N. Vannini· 1 shared P. Ginefra· 1 shared R. J. Brownlie· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

R. J. Salmond

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2 papers

Recent·Most cited

ImmunologybioRxivMar 30, 2022

TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells

H. C. Hope, G. Pickersgill, P. Ginefra…·R. J. Salmond

This study shows TGFβ suppresses Myc-driven metabolic changes in CD8+ T cells during activation by blocking amino acid uptake and glycolysis, while sparing mitochondrial respiration and mTOR activation.

DOI 10.3389/fimmu.2022.913184

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivFeb 28, 2020

Coordination of asparagine uptake and asparagine synthetase expression is required for T cell activation

H. C. Hope, R. J. Brownlie, L. Steele, R. J. Salmond

The paper shows that coordinated asparagine uptake and asparagine synthetase expression is necessary for optimal CD8+ T cell activation and effector responses.

DOI 10.1172/jci.insight.137761

humanproteomics

𝕏 PostBluesky