PARP1 Writes N3-Cytidine ADP-Ribosylation in DNA
Michael U. Musheev, Lars Schomacher, Johanna M. Schott, Amitava Basu, Martin Möeckel, Sabine Heinen, Laura Frosch, Peng Guo, Gaofan Yang, Qiuya Huang, Christof Niehrs
This study identifies PARP1's ability to ADP-ribosylate N3-deoxycytidine in ssDNA, leading to deamination products detectable by LC-MS/MS.
bioRxiv · Dec 19, 2025 · PreprintBiochemistry