Christof Niehrs

This study shows PARP10 and PARP15 modify RNA nucleobases in vitro and in cells, and TARG1 reverses these modifications.

This study identifies PARP1's ability to ADP-ribosylate N3-deoxycytidine in ssDNA, leading to deamination products detectable by LC-MS/MS.

This study shows that the N-terminus of Wnt proteins determines their secretion and signaling properties, with Wnt11's N-terminus enabling Evi/Wls-independent secretion and Frizzled 6 activation.

The paper demonstrates that mammalian DNA undergoes reversible N1-adenosine PARylation, identified through mass spectrometry and enzymatic analysis.

The paper develops DNA methylation clocks for clawed frogs, showing evolutionary conservation of epigenetic ageing mechanisms between frogs and mammals.

The paper improves m6A RNA modification detection using miCLIP2 and m6Aboost, identifying thousands of high-confidence sites in human and mouse cells without requiring Mettl3 depletion.

This study identifies R-spondins as BMP receptor antagonists, showing they inhibit BMP signaling via ZNRF3 and regulate dorsoventral axis formation in Xenopus embryos.