Author

George Samaan

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Aine Ni Scannail· 2 shared Djuna Katrina von MaydelliD· 2 shared Gwyneth WelchiD· 2 shared Julia Maeve BonneriD· 2 shared Li‐Huei TsaiiD· 2 shared Liwang Liu· 2 shared Noelle Leary· 2 shared Agnese GraziosiiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Aine Ni Scannail

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain

Djuna Katrina von Maydell, Shannon Wright, Ping‐Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu, Daniel Leible, Aine Ni Scannail, Mingpei Li, Carles A. Boix, Hansruedi Mathys, , Li‐Huei Tsai

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

bioRxiv · Sep 5, 2023 · PreprintNeuroscience

Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, Aine Ni Scannail, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna Katrina von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Julia Maeve Bonner, Li‐Huei Tsai

This study shows that APOE4 in microglia causes lipid accumulation, impairing their ability to monitor neuronal activity and leading to disrupted neuronal network function.

Cell stem cell · Aug 1, 2022Peer-reviewedNeuroscience