Author

Xochitl Luna

Whitehead Institute for Biomedical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:ChIP-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Olivia CorradiniD· 3 shared An T. Hoang· 2 shared Chesna Apere· 2 shared Chidera OkekeiD· 2 shared Deborah C. MashiD· 2 shared Hannah K. Ramcharan· 2 shared Megan Madden· 2 shared Wenjuan Du· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Olivia CorradinORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Variation in enhancer activity across brain regions defines neurological disease risk and shapes cellular pathology

Hannah K. Ramcharan, Yasmine N. Sami, Kathryn Hazel, Chidera Okeke, Zia Barnard, An T. Hoang, Scott McCallum, Chesna Apere, Wenjuan Du, Megan Madden, Yike Huang, Xochitl Luna, Gesmira Molla, Deborah C. Mash, Olivia Corradin

The paper identifies brain region-specific enhancers linked to neurological disease risk and shows their role in cellular pathology using enhancer activity data and GWAS integration.

bioRxiv · Sep 22, 2026 · PreprintGenetics

Heterogeneous epigenetic variation converges on splicing dysregulation in opioid addiction

Fatir A. Qureshi, Chesna Apere, Chidera Okeke, Bibi S. Kassim, Marina Iskhakova, Richard C. Sallari, Maharshi Chakraborty, Laura Morgan, Zia Barnard, Xochitl Luna, Megan Madden, Pavanna G. Rotti, An T. Hoang, Hannah K. Ramcharan, Bryan C. Quach, , Olivia Corradin

This study identifies epigenetic variation linked to opioid overdose using H3K27ac profiling and machine learning, revealing splicing dysregulation and CELF5 as a key factor.

medRxiv · Dec 29, 2025 · PreprintGenetic & Genomic Medicine

Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia

Michael D. Gallagher, Xochitl Luna, Wenjuan Du, Kathryn E.A. Hazel, Moritz List, Zeynep Aydin, Orian Stapleton, Yiran Cheng, Bingbing Yuan, Keya Viswanathan, Heather R. Keys, George W. Bell, Dheeraj Malhotra, Richard A. Young, Rudolf Jaenisch, Olivia Corradin

The paper identifies cis and trans gene regulatory mechanisms in microglia linked to multiple sclerosis risk SNPs using computational and CRISPR perturbation approaches.

medRxiv · Jun 16, 2025 · PreprintGenetic & Genomic Medicine

Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, Aine Ni Scannail, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna Katrina von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Julia Maeve Bonner, Li‐Huei Tsai

This study shows that APOE4 in microglia causes lipid accumulation, impairing their ability to monitor neuronal activity and leading to disrupted neuronal network function.

Cell stem cell · Aug 1, 2022Peer-reviewedNeuroscience