Author

George Young

MRC London Institute of Medical Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Ivan AndrewiD· 2 shared Petra HájkováiD· 2 shared Ahmed AhmediD· 1 shared Alessandro VitrioloiD· 1 shared Alessia Valenti· 1 shared Alice PollardiD· 1 shared Andrea Foley· 1 shared Ben Jones· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

Ivan AndrewORCID

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Author profile →

4 papers

Recent·Most cited

Defective HIRA driven chromatin maintenance underlies age related decline in oocyte quality

Yuki Hatanaka, Yuko Takeda, Max Hannam, Erin Cutts, Buhe Nashun, Marian H. Dore, Ben Moyon, George Young, Pierre‐Olivier Estève, Sriharsa Pradhan, Mary Herbert, Petra Hájková

This study identifies HIRA SUMOylation as a cause of chromatin instability in aging oocytes, leading to reduced fertility, and shows similar defects in human oocytes.

bioRxiv · Sep 29, 2026 · PreprintDevelopmental Biology

Identification and functional assessment of GPCRs across human adipogenesis

Jie Wu, Murray Polkinghorne, Eunice Liew, Iona Davies, Lili Davies, George Young, Ivan Andrew, Laurence Game, Katharine Lazarus, Patricia Ortega, Ahmed Ahmed, David Carling, Tricia Tan, Ben Jones, Alice Pollard

This paper identifies and functionally assesses GPCRs during human adipogenesis, revealing novel expression patterns and therapeutic targets.

bioRxiv · Jul 23, 2026 · PreprintCell Biology

High resolution multi-scale profiling of embryonic germ cell-like cells derivation reveals pluripotent state transitions in humans

Sarah Stucchi, Lessly P. Sepulveda-Rincon, Camille Dion, Gaja Matassa, Alessia Valenti, Cristina Cheroni, Alessandro Vitriolo, Filippo Prazzoli, George Young, Marco Tullio Rigoli, Riccardo Nagni, Martina Ciprietti, Benedetta Muda, Zoe Heckhausen, Petra Hájková, , Harry G. Leitch

This paper establishes a defined feeder-free system to convert human PGC-like cells to pluripotent stem cells, tracking transcriptional and epigenomic transitions using multi-omic analysis.

Stem Cell Reports · Dec 19, 2025Peer-reviewedDevelopmental Biology

Systemic extracellular acidification is a hallmark of aging

Eliano dos Santos, Yining Xie, Enyuan Cao, Andrea Foley, Max E. Taylor, Ivan Andrew, George Young, Natalie L. Trevaskis, Helena M. Cochemé

This study identifies systemic extracellular acidification as a conserved aging hallmark in flies and mice, linking it to mortality and acidosis susceptibility.

bioRxiv · Sep 24, 2024 · PreprintPhysiology