Erin Cutts

This study identifies HIRA SUMOylation as a cause of chromatin instability in aging oocytes, leading to reduced fertility, and shows similar defects in human oocytes.

This study identifies a bipartite mechanism for condensin II activation in mitosis, showing how M18BP1 relieves autoinhibition and enables DNA loop formation.

This study shows that topo II binding kinetics oppositely regulate decatenation and relaxation activities through a trade-off between search efficiency and processivity.

This study investigates how TOP2 resolves DNA braids and shows cohesin inhibits its activity by preventing substrate access.

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

The paper identifies a conserved mechanism by which KIF4A activates condensin I through direct binding to NCAPG and displacement of auto-inhibitory interactions.

This study investigates the role of HSV-1 UL9 in DNA looping and finds it does not efficiently loop oriS but can form large loops at non-origin sequences and tether intermolecular oriS DNA.

The paper shows condensin creates a short negatively supercoiled DNA loop during ATP usage, which may merge with an extruding loop.

The paper develops a quantitative binding model for the Apl protein of bacteriophage 186, revealing its binding energy, cooperativity, and DNA bending properties through in vitro and in vivo analyses.

The paper shows TFIIIC binding to Alu elements regulates gene expression through chromatin looping and histone acetylation during serum starvation.