Comprehensive identification of β-lactam antibiotic polypharmacology in Mycobacterium tuberculosis
Kaylyn L. Devlin, Emily Hutchinson, Hailey N. Dearing, Samantha R. Levine, Deseree J. Reid, Damon T. Leach, Lydia H. Griggs, Gerard X. Lomas, Leo J. Gorham, Aaron Wright, Gyanu Lamichhane, Vivian Lin, Kimberly E. Beatty
This study identifies 30 Mtb enzymes inhibited by meropenem, revealing polypharmacology beyond known cell wall targets.
ACS Infectious Diseases · Aug 18, 2025Peer-reviewedBiochemistry