A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease
Michele Biagioli, Cristina Di Giorgio, Carmen Massa, Silvia Marchianò, Rachele Bellini, Martina Bordoni, Ginevra Urbani, Rosalinda Roselli, Ginevra Lachi, Elva Morretta, Fabrizio Dal Piaz, Bruno Charlier, Bianca Fiorillo, Bruno Catalanotti, Luigi Cari, , Stefano Fiorucci
This study identifies 3-oxo-DCA as a microbial bile acid that acts as a GPBAR1 agonist and RORγt inverse agonist, reversing inflammation in IBD.
Biomedicine & Pharmacotherapy · Dec 1, 2024Peer-reviewedImmunology