Author

Angela Zampella

University of Naples Federico IIORCID 0000-0002-6170-279XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Approach:mixed model· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Bruno CatalanottiiD· 3 shared Stefano FiorucciiD· 3 shared Valentina SepeiD· 3 shared Bianca FiorilloiD· 2 shared Carmen Massa· 2 shared Cristina Di GiorgioiD· 2 shared Eleonora Distrutti· 2 shared Elva MorrettaiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

Bruno CatalanottiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BioinformaticsACS OmegaPeer-reviewedAug 13, 2026

From Structure to Dynamics: Activation Mechanism of the G Protein-Coupled Bile Acid Receptor 1-Gs Complex

Bianca Fiorillo, Federica Moraca, Francesco Saverio Di Leva…·Bruno Catalanotti

This study investigates how lithocholic acid modulates GPBAR1 activation and G protein engagement through molecular dynamics simulations and structural analysis.

DOI 10.1021/acsomega.6c02725

protein structuremixed model

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ImmunologyBiomedicine & PharmacotherapyPeer-reviewedDec 1, 2024

A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease

Michele Biagioli, Cristina Di Giorgio, Carmen Massa…·Stefano Fiorucci

This study identifies 3-oxo-DCA as a microbial bile acid that acts as a GPBAR1 agonist and RORγt inverse agonist, reversing inflammation in IBD.

54 citationstop 1%

mousemetabolomics

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Cancer BiologyBiochemical PharmacologyPeer-reviewedMar 15, 2024

Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis

Cristina Di Giorgio, Elva Morretta, Antonio Lupia…·Stefano Fiorucci

The paper shows bile acids, specifically GDCA, inhibit LIFR in gastric cancer, suggesting potential for bile acid-based therapies in LIF-driven oncogenesis.

22 citations

humanorganoid / primary culture

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