Author

Golnaz Hesami

Justus-Liebig-Universität Gießen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Rajkumar SavaiiD· 2 shared Soni Savai PullamsettiiD· 2 shared Werner SeegeriD· 2 shared Andreas Michael ZeiheriD· 1 shared Anoop Vadakan Cherian· 1 shared Astrid WietelmanniD· 1 shared Carsten Müller‐TidowiD· 1 shared Chanil ValasarajaniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Rajkumar SavaiORCID

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2 papers

Recent·Most cited

Targeting ADORA-PDE10 cAMP Microdomain: A Novel Therapeutic Approach for Pulmonary Hypertension

Chanil Valasarajan, Golnaz Hesami, Giovanni Maroli, Anoop Vadakan Cherian, Julio Castro Palomino Laria, Nahomi Castro Palomino Laria, Astrid Wietelmann, Leoni Gnatzy-Feik, Stephan Rosenkranz, Rajkumar Savai, Werner Seeger, Soni Savai Pullamsetti

This study shows that targeting ADORA1 and PDE10A together improves PAH symptoms in animal models by increasing cAMP levels and reducing vascular remodeling.

bioRxiv · Oct 27, 2024 · PreprintMolecular Biology

Metabolic alterations drive inflammatory phenotypes in CHIP-associated heart failure

Siavash Mansouri, Inga Hemmerling, Golnaz Hesami, Sebastian Cremer, Klara Kirschbaum, Stephan Klatt, Fatemeh Behjati Ardakani, Marcel H. Schulz, Xue Li, Marina Scheller, Carsten Müller‐Tidow, Philipp Friedrich Arndt, Stefan Günther, Manju Padmasekar, Mario Looso, , Soni Savai Pullamsetti

This study shows that DNMT3A mutations in CHIP lead to metabolic changes in macrophages that drive inflammation, and targeting these changes can improve heart failure outcomes.

bioRxiv · Jul 30, 2024 · PreprintMolecular Biology